Literature

VpsT Is a Transcriptional Regulator Required for Expression of vps Biosynthesis Genes and the Development of Rugose Colonial Morphology in Vibrio cholerae O1 El Tor.
Catharina Casper-Lindley, 2004.Vibrio cholerae switches between smooth and rugose colonial variants . The rugose variant produces more vibrio polysaccharides [VPS^{El Tor}] and forms well-developed biofilms . Both phenotypes depend on expression of vps biosynthesis genes . We identified a positive transcriptional regulator of vps gene expression, VpsT, which is homologous to response regulators of two-component regulatory systems . Disruption of vpsT in the rugose variant yields smooth colonies, prevents formation of mature biofilms, and decreases vps gene expression . The interaction between VpsT and VpsR, a previously identified positive regulator of vps genes, was also investigated.

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Last modified: May 25, 2005