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A MecA Paralog, YpbH, Binds ClpC, Affecting both Competence and Sporulation.
Marjan Persuh, 2002.ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA . The genome of Bacillus subtilis contains a paralog of mecA, ypbH . We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation .

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