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Antibiotic Susceptibility in Neonatal Invasive Isolates of Streptococcus agalactiae in a 2-Year Nationwide Surveillance Study in Germany. Kirsten Fluegge, 2004.The antimicrobial susceptibility of 296 invasive neonatal group B streptococcus isolates from a nationwide 2-year surveillance study in Germany was investigated . All isolates were susceptible to beta-lactams, linezolid, quinupristin-dalfopristin, and vancomycin . Erythromycin and clindamycin resistance was found in 10.1 and 5.7%, respectively . The ermB, ermTR, or mefA gene was detected in all but one of the erythromycin-resistant isolates . A SecE Mutation That Modulates SecY-SecE Translocase Assembly, Identified as a Specific Suppressor of SecY Defects. Hiroyuki Mori, 2003.The SecY39(Cs) (cold-sensitive) alteration of Arg357 results in a defect of translocation initiation . As a means to dissect the Sec translocation machinery, we isolated mutations that act as suppressors of the secY39 defect . A specific secE mutation, designated secE105, was thus isolated . This mutation proved to be identical with the prlG2 mutation and to suppress a number of cold-sensitive secY mutations . However, other prlG mutations did not effectively suppress the secY defects . Evidence indicates that the Ser105-to-Pro alteration in the C-terminal transmembrane segment of SecE weakens SecY-SecE association . In vitro analyses showed that the SecE(S105P) alteration preferentially stimulates the initial phase of translocation . It is suggested that the S105P alteration affects the SecYEG channel such that it is more prone to open and to accept the translocation initiation domain of a preprotein molecule .
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