Abstracts. Tanirbergenov, T.B.

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Tanirbergenov, T.B., Vasil'jeva, S.V., Kostyanovski, R.G., Rapoport, I., Huttunen, T. and Hukki-Immonen, O., [Regularities of mutagenic and toxic effects of ethyleneimine and its oligomers. A comparative study on the automated system SOS-chromotest and in standard bacterial test systems], (Russ.), Genetika, 1988, vol. 24, (4), pp. 763-765

ABSTRACT

Raising total positive charge of a chemical mutagen does increase its local concentration in the area of biological target-DNA, and, as a consequence, causes increase in the rate of interaction of a mutagen with the target. Experimental evidence of this idea has been obtained in three test systems: the Ames test, Trp+ reversions in Escherichia coli WP2 and in the automated "SOS-chromotest" system with E. coli PQ 37 ("Labsystems", Finland).

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