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Scientific
Publications - Work Done by Microbiology Reader
R.J.W. Lambert and M.D. Johnston, The effect of interfering substances on the disinfection process a mathematical model, Journal of Applied Microbiology, Volume 91, Issue 3, Page 548-555, Sep 2001 ABSTRACT AIMS: To gain a greater understanding of the effect of
interfering substances on the efficacy of disinfection. METHODS AND RESULTS:
Current kinetic disinfection models were augmented by a term designed to
quantify the deleterious effect of soils such as milk on the disinfection
process of suspended organisms. The model was based on the assumption that
inactivation by added soil occurred at a much faster rate than microbial
inactivation. The new model, the fat-soil model, was also able to quantify the
effect of changing the initial inoculum size (1 x 10(7)-5 x 10(7) ml(-1) of
Staphylococcus aureus) on the outcome of the suspension tests. Addition of
catalase to the disinfection of Escherichia coli by hydrogen peroxide, resulted
in changes to the shape of the log survivor/time plots. These changes were
modelled on the basis of changing biocide concentration commensurate with
microbial inactivation. CONCLUSIONS: The reduction in efficacy of a disinfectant
in the presence of an interfering substance can be quantified through the use of
adaptations to current disinfection models. SIGNIFICANCE AND IMPACT OF THE
STUDY: Understanding the effect of soil on disinfection efficacy allows us to
understand the limitations of disinfectants and disinfection procedures. It also
gives us a mechanism with which to investigate the soil tolerance of new
biocides and formulations.
(order Full Text from publisher)
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