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Scientific
Publications - Work Done by Microbiology Reader
R.J.W. Lambert, J. Joynson and B. Forbes, The relationships and susceptibilities of some industrial, laboratory and clinical isolates of Pseudomonas aeruginosa to some antibiotics and biocides, Journal of Applied Microbiology, Volume 91, Issue 6, Page 972-984, Dec 2001 ABSTRACT AIMS: To provide evidence to support or refute the hypothesis
that cross-resistance between antibiotics and biocides can occur. METHODS AND
RESULTS: Fifty-five strains of Pseudomonas aeruginosa were tested for their
resistance to anti-pseudomonal antibacterials. Twenty clinical, 19 industrial
and 16 culture collection isolates were used. The MIC was found for the
antibiotics amikacin, ceftazidime, ciprofloxacin, gentamycin, ticarcillin,
tobramycin, imipenem and polymyxin B. The MIC was also found for the biocides
benzalkonium chloride and chlorhexidine. The analysis of the data was based on
the production of a normal distribution of the log (MIC) plots for each
antimicrobial. Strains were then labelled as resistant, intermediate or
sensitive based on the mean and standard deviation of the distributions.
CONCLUSIONS: In general the clinical isolates were the most recalcitrant
organisms, with the industrial isolates being the most sensitive. SIGNIFICANCE
AND IMPACT OF THE STUDY: The work shows that antibiotic/biocide correlations do
occur, especially with clinical strains. That such correlations were not found
with industrial isolates suggests that the clinical environment is responsible
for the correlation. We could infer that it is the selective pressure of
antibiotic usage that differentiates the clinical environment from the
industrial.
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