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Scientific
Publications - Work Done by Microbiology Reader
Nylund, L., Heikkilä, P., Hämeilä, M., Pyy, L., Linnainmaa, K. and Sorsa, M., Genotoxic effects and chemical compositions of four creosotes, Mutation Research, 1992, vol. 265, pp. 223-236 ABSTRACT Four creosotes used in Finland for impregnating wood were tested
in the Ames Salmonella test, the SCE test and the SOS chromotest. Compounds
volatile at 37 degrees C were assayed using the taped plate testing protocol.
The creosotes were fractionated according to their natural boiling ranges and
the fractions were tested in the Ames Salmonella assay. Chemical compositions of
creosotes and fractions were determined by high resolution gas
chromatography/mass spectrophotometry techniques and by reversed phase high
performance liquid chromatography. Mutagenic activities were shown to reside in
fractions having the highest boiling point ranges (greater than 290 degrees C).
The concentrations of mutagenic polycyclic aromatic hydrocarbons in creosotes
and in some of their corresponding distillation fractions, when compared with
mutagenic activities, indicated synergistic or antagonistic interactions.
(order Full Text from publisher)
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