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Scientific
Publications - Work Done by Microbiology Reader
Jakob, R. and Lindl, T., [In vitro- toxicity test of 25 compounds with an automated system], Ein automatisierter in vitro-toxizitätstest von 25 chemikalien, (Ger.), Zentralblatt für Hygiene and Umweltmedizin, 1990, vol. 190, (5-6), pp. 536-546 ABSTRACT A computer controlled bench-top analyser was used to establish
an automated in vitro-cytotoxicity test. It is based on the continuous
monitoring of growth of Salmonella typhimurium TA 98 and TA 100 (strains that
are also employed in the classical Ames test (1) for mutagenicity screening)
under the influence of the toxic compounds. With this method we can quantify
general cytotoxicity and in addition, some questions concerning the mechanism of
the toxic influence on the test organisms can be answered. Its simplicity and
reliability as well as the good correlation with in vivo data make the new test
system suitable for pre-screening the toxicity of a large number of compounds
within short time.
(order Full Text from publisher)
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