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Scientific
Publications - Work Done by Microbiology Reader
Chiron J, Lamande J, Moussa F, Trivin F, Ceolin R, [Effect of "micronized" C60 fullerene on the microbial growth in vitro] (French), Annales pharmaceutiques francaises, 2000, May, 58(3), 170-175 ABSTRACT The effect of C60 "micronized fullerene was tested by a
manual and automatised (Analyzer Bioscreen C(R)) micromethod on the microbial
growth of 22 collection strains: E. coli (5), P. aeruginosa (2), S. Typhimurium
(6), S. aureus (2), L. monocytogenes (2), E. hirae (1), B. cereus (1), B.
subtilis (1), B. pumilus (1) et C. albicans (1). No effect on microbial growth
was observed with C60 "micronized fullerene (43.2 microg/ml) on all strains
studied: no difference was found with doubling time, slope and growth rate
constant. The results of cytotoxicity obtained with animal models or in vitro
cultures as human monocyte, leukocyte or macrophage confirm the absence of
effect of C60 fullerene at a concentration compatible with microbial or
biological models. This study is included in research program headed
"Therapeutics perspectives of fullerenes.
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