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Scientific Publications - Work Done by Microbiology Reader Bioscreen C

 

Alla Aroutcheva, Jose A. Simoes , Susan Shott , Sebastian Faro, The inhibitory effect of clindamycin on Lactobacillus in vitro, Infectious Diseases in Obstetrics & Gynecology, Volume 9, Number 4, December 01, 2001 , Pages: 239-244

ABSTRACT

Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp.

Methods: Concentrations of clindamycin ranging from 1.95-20 000 wg/ml were studied for their effect on the growth of six strains of Lactobacillus.

Results: Clindamycin concentrations between 1.95-31.25 wg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 wg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 wg/ml.

Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.

 

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Last modified: May 25, 2005