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Sequential Therapy with Caspofungin and Fluconazole for Candida albicans Infection.
Francesco Barchiesi, 2004.A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated . Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration . Our data suggest that switching from CAS to FLC is a potentially explorable therapeutic option for treatment of systemic candidiasis .

An Integrated Structural and Computational Study of the Thermostability of Two Thioredoxin Mutants from Alicyclobacillus acidocaldarius.
Simonetta Bartolucci, 2003.We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx . Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein .

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Last modified: May 25, 2005