Bio Docs

Antistaphylococcal Activity of LBM415, a New Peptide Deformylase Inhibitor, Compared with Those of Other Agents.
Kim Credito, 2004.The MICs of LBM415, a new peptide diformylase inhibitor, were

0.06 to 4.0 µg/ml for 258 isolates of Staphylococcus aureus and coagulase-negative staphylococci . LBM415 MICs were similar irrespective of whether the strains were methicillin susceptible or resistant . All strains were also susceptible to vancomycin, linezolid, ranbezolid, daptomycin, oritavancin, and quinupristin-dalfopristin . LBM415 at the MIC was bacteriostatic after 24 h .

The mef(A) Gene Predominates among Seven Macrolide Resistance Genes Identified in Gram-Negative Strains Representing 13 Genera, Isolated from Healthy Portuguese Children.
K. K. Ojo, 2004.Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study . These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine samples . The mef(A) gene, coding for an efflux protein, was found in 73 isolates (41%) and was the most frequently carried gene . The mef(A) gene could be transferred from the donors into a gram-positive E . faecalis recipient and a gram-negative Escherichia coli recipient . The erm(B) gene transferred and was maintained in the E . coli transconjugants but was found in 0 to 100% of the E . faecalis transconjugants tested, while the other five genes could be transferred only into the E . coli recipient . The individual macrolide resistance genes were identified in 3 to 12 new genera . Eight (10%) of the oral isolates and 30 (34%) of the urine isolates for which the MICs were 2 to >500 µg of erythromycin per ml did not hybridize with any of the seven genes and may carry novel macrolide resistance genes .

Degradation of Alkyl Ethers, Aralkyl Ethers, and Dibenzyl Ether by Rhodococcus sp . Strain DEE5151, Isolated from Diethyl Ether-Containing Enrichment Cultures.
Yong-Hak Kim, 2004.

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Last modified: May 25, 2005