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DNA Microarray Analysis of the Expression Profile of Escherichia coli in Response to Treatment with 4,5-Dihydroxy-2-Cyclopenten-1-One. Sangita Phadtare, 2002.We carried out DNA microarray-based global transcript profiling of Escherichia coli in response to 4,5-dihydroxy-2-cyclopenten-1-one to explore the manifestation of its antibacterial activity . We show that it has widespread effects in E . coli affecting genes encoding proteins involved in cell metabolism and membrane synthesis and functions . Genes belonging to the regulon involved in synthesis of Cys are upregulated . In addition, rpoS and RpoS-regulated genes responding to various stresses and a number of genes responding to oxidative stress are upregulated . The Solution Structure of YbcJ from Escherichia coli Reveals a Recently Discovered  L Motif Involved in RNA Binding.Laurent Volpon, 2003.The structure of the recombinant Escherichia coli protein YbcJ, a representative of a conserved family of bacterial proteins (COG2501), was determined by nuclear magnetic resonance . The fold of YbcJ identified it as a member of the larger family of S4-like RNA binding domains . These domains bind to structured RNA, such as that found in tRNA, rRNA, and a pseudoknot of mRNA . The structure of YbcJ revealed a highly conserved patch of basic residues, comprising amino acids K26, K38, R55, K56, and K59, which likely participate in RNA binding .
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